April 30, 2024

Testosterone Pills: Meet Kyzatrex® a New Oral Testosterone Therapy

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Written By


photo of Vinita Tandon, MD

Medically Reviewed By

Vinita Tandon, MD

Lifeforce Medical Director

Testosterone Pills: Meet Kyzatrex® a New Oral Testosterone Therapy

What Is Kyzatrex® New Oral Testosterone Pill?

Roughly 40% of men over the age of 45 have lower-than-ideal testosterone levels, according to a 2022 Annals of Medicine & Surgery report. While low T levels are common, the symptoms — such as low sex drive, muscle loss, and low energy — can make it difficult to go about your day-to-day. 

But correcting your low T doesn't have to involve painful injectables or messy creams. Kyzatrex®'s new oral testosterone pill is FDA-approved and makes raising your T to a healthy range as simple as popping a pill. While older TRT capsules were linked to liver toxicity, newer oral TRT meds including Kyzatrex® bypass the liver, deeming them a safer (and still effective) option. 

Here's everything you need to know about Kyzatrex®’s new oral testosterone pill.

What Is Oral TRT?

Oral testosterone replacement therapy, or oral TRT, is a method of delivering testosterone medication through a pill or capsule that you take by mouth. It is used to treat hypogonadism, a condition characterized by low or no testosterone in adult males.

Kyzatrex® is a type of oral TRT that was approved by the FDA in August 2022 to treat hypogonadism. Kyzatrex® is taken by mouth twice a day, once in the morning and once in the evening, with a meal. Kyzatrex® is approved in three dosage strengths — 100 mg, 150 mg, and 200 mg — and your doctor will prescribe the appropriate dosage based on your starting testosterone levels. 

Can You Take Testosterone Orally?

TRT is available in many different formulations, including skin patches, injections, pellet implantations, and nasal gels — and it's also available in capsules that you take orally. Kyzatrex® is one type of oral TRT medication, and it comes as a liquid-filled capsule that you take twice a day.

While you can take testosterone orally, it's not one of the first-line treatments because it's usually not covered by insurance. Still, oral TRT remains a safe and easy way for people with hypogonadism to correct their T levels — and in some cases, insurance might cover the treatment if other testosterone replacement methods haven't worked for you.

Consider speaking to your doctor about switching to oral TRT if:

  • You're afraid of needles.

  • You've experienced side effects from traditional TRT formulations, like patches and injections.

  • You're concerned about a topical treatment (like gels or creams) transferring to other members of your household.

What is Kyzatrex New Oral Testosterone Pill


Does Oral Testosterone Work?

Yes, oral TRT is a safe and effective way to correct low testosterone levels. A 2021 study in the Journal of Clinical Hypertension reports that Kyzatrex® raised testosterone levels to a healthy range in 96% of men with hypogonadism after three months of treatment.

Oral TRT is absorbed instantly through the digestive and lymphatic system. And unlike other TRT formulations, it completely bypasses the liver and doesn't pose a risk for liver toxicity, per the Cleveland Clinic

One of the main advantages of oral T pills is that they're convenient and easy to take. With Kyzatrex®, you simply take two capsules per day along with a meal to help the medication absorb better.

What Do Testosterone Pills Do?

Testosterone pills raise your blood testosterone levels. Testosterone is a sex hormone produced by the testes in males (and in smaller amounts in the ovaries in females) that helps regulate sex drive, bone mass, muscle mass and strength, and it helps produce red blood cells and sperm.

A testosterone deficiency can manifest itself in many ways, including low libido, lower bone density, muscle mass decline, and increased body fat, per the National Institutes of Health (NIH). While it's normal for T levels to drop with age, people can experience lower testosterone levels due to medical conditions, in which case, a doctor may prescribe oral testosterone pills to correct the deficiency.

Read more about new Kyzatrex oral testosterone pill here →

what is testosterone undecanoate

What Is Kyzatrex?

Kyzatrex® is a new medication formulated to help men struggling with symptoms of low testosterone, a condition that can disrupt numerous areas of quality of life, including energy, focus, strength, mood, and more. Kyzatrex® focuses on treatment via an oral method of testosterone therapy. What makes Kyzatrex® so unique is that it comes in an easy-to-swallow capsule — a breakthrough in testosterone replacement therapy, which was previously limited to cumbersome injections and messy creams or gels. Additionally, Kyzatrex® was created for flexible dosing, allowing users to get their optimal dose without the need to measure the milliliters pulled into a syringe, or count the pumps of gels and creams. It’s clear that Kyzatrex® has revolutionized testosterone optimization in a way that makes it easier than ever to be the man you used to be. 

Why Choose Kyzatrex®?

So, why should Kyzatrex® be on your radar if you're exploring testosterone therapy options? First, its pill form is a game changer. No more sore thighs from frequent injections or daily applications with gels. Instead, you can simply pop a pill twice daily (with food), and go on with your day. Plus, Kyzatrex® works efficiently to boost your testosterone to levels that can help improve your energy, mood, and libido. It’s designed to mimic the natural rhythm of your body, giving you a more "normal" feeling day in and day out, not to mention less side effects than other testosterone treatments. This “normal” feeling that Kyzatrex® provides is due to the fact that it is absorbed in the small intestine, which helps prevent the strong wave of unnatural and startling feelings that can sometimes be brought on by quick-acting injections or creams.

Benefits of Kyzatrex®

- More favorable patient reported outcomes
- Flexible dosages
- Small intestine absorption
- Fewer side effects- Keeps testosterone levels high regardless of fat consumption
- Delivered to your home- Easily transportable

All About Testosterone Pills for Men


How Much Does Kyzatrex® Cost?

Kyzatrex® isn’t the cheapest option out there, but it’s competitive, especially considering the convenience it offers. Typically, treatment can run $400 to $600 per month if insurance doesn't cover it. However, don't let sticker shock keep you from reaching your full potential. With the Lifeforce Membership, members are able to work with a clinician that will review your 50+ biomarkers to determine if Kyzatrex® is right for you.

Kyzatrex® Reviews

Hearing from people who've actually used Kyzatrex® can be incredibly helpful. Overall, men taking Kyzatrex®, and testosterone replacement therapy more generally, report improved quality of life. Guys often mention feeling like they’ve got their mojo back, with more energy and better moods being a common theme. Of course, everyone’s experience is a bit different, and it’s important to keep that in mind. While many report positive changes, there are always a few who may not find it as effective or who experience side effects, but those who feel helped by Kyzatrex® often say they wished they had started earlier.

Kyzatrex® vs. Jatenzo®

When it comes down to choosing between Kyzatrex® and Jatenzo®, another oral testosterone replacement therapy, it’s like comparing apples to... well, slightly different apples. Both can help manage low testosterone levels effectively through a daily oral regimen. The main differences lie in their dosing requirements and potential side effects. It’s a good idea to have a detailed chat with your doctor about which might work better for your specific situation, considering your overall health and treatment goals.

Kyzatrex® Side Effects

No medication is without potential drawbacks, and Kyzatrex® is no exception. Common side effects include things like a rise in blood pressure, headaches, and maybe a bit of nausea. It can also impact your cholesterol levels and increase red blood cell counts, which need to be monitored. Serious side effects are rare, but they can happen, so it’s crucial to stay in close contact with your clinician, especially during the early stages of treatment.

Read more about Kyzatrex here →

man lifting weights

Testosterone Pills for Men

If you have low testosterone levels, also known as hypogonadism, your doctor might recommend starting testosterone replacement therapy (TRT). While first-line TRTs usually include creams, injections, pellet implantations, and nasal gels, these often come with unpleasant side effects that can make sticking to your treatments more difficult. If traditional TRT formulations don't quite work for you, you might want to try testosterone pills instead.

Testosterone pills, or oral TRT, are liquid-filled capsules that you swallow, just like with any other pill. They're only available via a prescription and are usually meant to be taken twice a day — once in the morning and once at night, with a meal. Some of the FDA-approved testosterone pills on the market include Kyzatrex®, Jatenzo, and Tlando.

Are Testosterone Pills Safe?

Kyzatrex® is FDA-approved and deemed safe and effective for the treatment of hypogonadism caused by medical conditions. Disorders of the testicles, pituitary gland, or brain can all potentially cause hypogonadism because these organs all play a role in producing testosterone.

The FDA has established these prescription pills safe and beneficial for men who are hypogonadal and symptomatic. 

While testosterone pills are FDA-approved, it doesn't mean this prescription is without side effects. Kyzatrex® was shown to minimally increase blood pressure readings by 2-3mm Hg, not requiring additional hypertension therapy in most people. 

Other side effects potentially associated with testosterone replacement  include increased red blood cell count (hematocrit), liver problems, edema in ankles and feet, painful and enlarged breast area, and sleep apnea.

Do Testosterone Pills Work?

Oral testosterone pills are clinically proven to raise blood levels of testosterone. So if you have low T levels — defined as less than 12 nmol/L or less than 300 ng/dL — due to a medical condition, taking testosterone pills can help bring your levels up to a healthy range.

A 2021 study in the Journal of Clinical Hypertension reports that Kyzatrex® raised testosterone levels to a healthy range in 96% of men with hypogonadism after three months of treatment. That means symptoms of low testosterone levels, such as low sex drive, erectile dysfunction, poor mood, and fatigue, can all improve after taking testosterone pills as directed.

What Are Testosterone Pills Used For?

Testosterone pills are used to treat hypogonadism caused by medical conditions. Testosterone pills work by raising the level of testosterone in your blood. So if you have hypogonadism, testosterone pills are an effective treatment to help correct the deficiency and alleviate symptoms associated with low testosterone levels. 

Common symptoms of low T levels include fatigue, mood issues, low sex drive, fat gain, loss of muscle mass, sleep issues, and hair loss, among others. TRT treatments such as testosterone pills can help bring your T levels up to a healthy range and reverse the symptoms associated with hypogonadism.

How Long Does It Take for Testosterone Pills to Work?

It can take as quickly as three to four weeks into treatment, but maximum benefits may take as long as six months to a year, per a 2011 European Journal of Endocrinology report. 

According to the study, people on TRT saw improvements in libido after six weeks, while effects on mood take around three to six weeks. Body composition improvements — think: losing fat and gaining muscle and strength — occur within 12 of 16 weeks of therapy, according to the European Journal of Endocrinology report.

Read more about testosterone pills for men here →


Commonly asked questions about Kyzatrex and testosterone replacement therapy

What makes Kyzatrex® different from other testosterone replacement therapies?

Kyzatrex® is a new oral testosterone therapy that offers a convenient alternative to traditional testosterone replacement therapies (TRTs) like injections, creams, or gels. Unlike older oral TRT capsules that were linked to liver toxicity, Kyzatrex® bypasses the liver, making it a safer option. It is taken as a liquid-filled capsule twice a day with a meal, which simplifies the process of testosterone administration without the need for needles or messy applications.

What are the potential side effects of taking Kyzatrex®?

How quickly can I expect to see results from taking Kyzatrex®?

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Hormone Optimization

Kyzatrex® is an FDA-approved oral testosterone treatment. It is a unique formulation that is highly bioavailable and convenient to administer. It is prescribed for men with low levels of testosterone who are symptomatic and have no contraindications to hormone therapy. Clinical trials revealed 96% of men treated with Kyzatrex® were able to restore their testosterone levels to a normal range. With painless administration and flexible dosing, Kyzatrex® is considered a first-line choice for many men.

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